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KMID : 0361020100530060344
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Korean Journal of Otolaryngology - Head and Neck Surgery
2010 Volume.53 No. 6 p.344 ~ p.348
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Distribution of Histologic Type of Nasal Polyp and Expression of Vascular Endothelial Growth Factor According to Nasal Polyp Type
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Heo Kyung-Wook
Kang Mi-Seon
Park Seong-Kook
Kwak Hyun-Ho
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Abstract
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Background and Objectives: ZZTo determine the frequency of the histologic types of nasal polyp in Korea and their relationships with respect to age, laterality, asthma, allergic rhinitis (AR) and expression of vascular endothelial growth factor (VEGF).
Subjects and Method: ZZTissue slides obtained from 282 patients with nasal polyps were examined; polyps were classified either as eosinophilic polyp or chronic inflammatory polyp. VEGF expression was determined using immunohistochemical staining.
Results: ZZOf the 282 subjects, 169 (59.9%) had chronic inflammatory polyps, 113 (40.1%) had eosinophilic polyps, and 232 (82.3%) had bilateral polyps. Twenty-two subjects (7.8%) had asthma and 23 (8.2%) had AR. There was no statistical relationship between nasal polyp type and laterality or the presence of asthma or AR. Of 10 children, 9 (90%) had chronic inflammatory polyps. VEGF expression was significantly higher in eosinophilic polyps than in chronic inflammatory polyps, and significantly higher in the samples of each polyp type from the subjects with AR than those without AR. In subjects with asthma, however, the VEGF expression did not differ between eosinophilic polyps and chronic inflammatory polyp samples.
Conclusion: ZZIn the Korean population, chronic inflammatory nasal polyps are more common than eosinophilic nasal polyps. VEGF expression was the highest in eosinophilic polyps of the subjects with AR, suggesting that VEGF might contribute to the polyp formation via local allergic action.
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KEYWORD
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Nasal polyp, Pathology, Vascular endothelial growth factor, Inflammation, Allergy
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